The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial

The current study investigated the impact of different doses of seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. The study was a double-blind placebo-controlled clinical trial. Patients with mild and asymptomatic SARS-CoV-2 infecti...

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Bibliographic Details
Published in:International journal of environmental research and public health 2022-09, Vol.19 (18), p.11798
Main Authors: Bin Abdulrahman, Khalid A, Bamosa, Abdullah Omar, Bukhari, Abdullah I, Siddiqui, Intisar Ahmad, Arafa, Mostafa A, Mohsin, Ashfaq A, Althageel, Mamdouh Faleh, Aljuaeed, Majed Owed, Aldeailej, Ibrahim Mohammed, Alrajeh, Abdulaziz Ibrahim, Aldosari, Kamel Mohamed, Hawsawi, Najat Ahmed, Zawbaee, Khalid Ibrahim, Alsurayea, Saad Mohammed
Format: Article
Language:English
Subjects:
Biological Products
Cell culture
Charcoal
Clinical trials
Coronaviruses
COVID-19
COVID-19 Drug Treatment
Differentiation
Double-Blind Method
Double-blind studies
Health services
Hepatitis C
Humans
Infections
Inflammation
Markers
Morning
Natural products
Nigella sativa
Pandemics
Patients
Phytotherapy
Powder
Powders
Procalcitonin
Quarantine
Questionnaires
SARS-CoV-2
Seeds
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Subgroups
Viral diseases
Viruses
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Summary:The current study investigated the impact of different doses of seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. The study was a double-blind placebo-controlled clinical trial. Patients with mild and asymptomatic SARS-CoV-2 infection patients were randomly subdivided into seven subgroups: Group (GP) 1: received charcoal capsules as a control group, and GP 2: received three capsules of whole seeds daily, two capsules in the morning and one in the evening; GP 3: received three capsules of whole seeds every 12 h, GP 4: received five capsules in the morning and four capsules of whole seeds in the evening, GP 5: received one capsule of powder every 12 h; GP 6: received two capsules of powder every 12 h; GP 7: received three capsules of powder every 12 h; all treatment course was for ten days. Inflammatory parameters were assessed before and after interventions. 262 subjects were included in the final analysis. No significant difference was detected regarding age, gender, and nationality. No significant differences were detected between the inflammatory marker in all groups. The WBCs showed a significant difference between before and after the intervention. While for procalcitonin, a significant difference was demonstrated in groups 1,4, and 6. The current randomized clinical trial did not reveal a significant effect of ten days of treatment with various doses of on symptoms, differentiation profile, and inflammatory markers of patients with COVID-19. As a natural product, the effect of on disease requires weeks to manifest itself.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph191811798