LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients

Lysil oxidase like enzyme-2 (LOXL-2) and TNC-C play important roles in organ fibrosis. We assessed circulating LOXL-2 and TNC-C levels and their relationship to fibrosis severity in HIV- and/or HCV-infected individuals. Healthy controls (n = 22), HIV mono- (n = 15), HCV mono- (n = 52) and HCV/HIV-co...

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Published in:Biomarkers in medicine 2022-08, Vol.16 (11), p.839-846
Main Authors: Altinbas, Akif, Holmes, Jacinta A, Salloum, Shadi, Lidofsky, Anna, Alatrakchi, Nadia, Somsouk, Ma, Hunt, Peter, Deeks, Steven, Chew, Kara W, Lauer, Georg, Kruger, Annie, Lin, Wenyu, Chung, Raymond T
Format: Article
Language:English
Subjects:
antiretroviral therapy
Biomarkers
Coinfection
Fibrosis
Hepatitis C - complications
hepatitis C virus infection
HIV infection
HIV Infections - complications
Humans
Liver Cirrhosis - complications
Liver Cirrhosis - diagnosis
liver fibrosis
LOXL-2
peginterferon and ribavirin therapy
TNC-C
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Summary:Lysil oxidase like enzyme-2 (LOXL-2) and TNC-C play important roles in organ fibrosis. We assessed circulating LOXL-2 and TNC-C levels and their relationship to fibrosis severity in HIV- and/or HCV-infected individuals. Healthy controls (n = 22), HIV mono- (n = 15), HCV mono- (n = 52) and HCV/HIV-co-infected (n = 92) subjects were included. LOXL-2 and TNC-C levels were significantly higher in HCV mono- and HCV/HIV-co-infected individuals with F0 compared to healthy controls. In addition, in HCV/HIV-co-infected individuals, LOXL-2 levels were higher in intermediate fibrosis compared to no/mild fibrosis. In HCV/HIV-co-infected study participants, both LOXL-2 and TNC-C were significantly higher in intermediate fibrosis compared to no/mild fibrosis, but did not further increase with advanced fibrosis. Furthermore, both markers were elevated among HCV/HIV-positive individuals with mild/no fibrosis.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2021-0596