Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc

MYC drives the tumorigenesis of human cancers, including prostate cancer (PrCa), thus deubiquitinase (DUB) that maintains high level of c-Myc oncoprotein is a rational therapeutic target. Several ubiquitin-specific protease (USP) family members of DUB have been reported to deubiquitinate c-Myc, but...

Full description

Bibliographic Details

Published in:	Cell death and differentiation 2022-09, Vol.29 (9), p.1730-1743
Main Authors:	Peng, Yunhua, Liu, Jing, Wang, Zhen, Cui, Chunping, Zhang, Tiantian, Zhang, Shuangxi, Gao, Peipei, Hou, Zhanwu, Liu, Huadong, Guo, Jianping, Zhang, Jinfang, Wen, Yurong, Wei, Wenyi, Zhang, Lingqiang, Liu, Jiankang, Long, Jiangang
Format:	Article
Language:	eng
Subjects:	Animals c-Myc protein Carcinogenesis - genetics Carcinogenesis - metabolism Deubiquitinating Enzymes - metabolism Gene Expression Regulation, Neoplastic Humans Male Mice Mice, Transgenic Myc protein Oncogenes Physiology Prostate Prostate - metabolism Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Therapeutic applications Therapeutic targets Transgenic mice Tumorigenesis Ubiquitin Ubiquitin-specific proteinase
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!