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Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a fea...
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| Published in: | Brazilian journal of microbiology 2022-12, Vol.53 (4), p.2003-2008 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c381t-e5289556b5ddb86a94924f09e40dcedc7a8aaa9d797108fe27b9337d3d3a4e433 |
| container_end_page | 2008 |
| container_issue | 4 |
| container_start_page | 2003 |
| container_title | Brazilian journal of microbiology |
| container_volume | 53 |
| creator | Alanís-Ríos, Sergio A. González, Gloria M. Andrade, Angel Becerril-García, Miguel A. Bonifaz, Alexandro Robledo-Leal, Efrén R. Montoya, Alexandra M. Treviño-Rangel, Rogelio de J. |
| description | Candida auris
is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of
C. auris
. Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indifferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating
C. auris
infections. |
| doi_str_mv | 10.1007/s42770-022-00817-y |
| format | article |
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is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of
C. auris
. Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indifferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating
C. auris
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is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of
C. auris
. Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indifferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating
C. auris
infections.</description><subject>Antagonism</subject><subject>Antidepressants</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Biomedical and Life Sciences</subject><subject>Candida auris</subject><subject>Clinical isolates</subject><subject>Clinical Microbiology - Short Communication</subject><subject>Food Microbiology</subject><subject>Fungal infections</subject><subject>Fungicides</subject><subject>Health risks</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Micafungin</subject><subject>Microbial Ecology</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Mycology</subject><subject>Public health</subject><subject>Sertraline</subject><subject>Voriconazole</subject><subject>Yeasts</subject><issn>1517-8382</issn><issn>1678-4405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUtv1TAQhSMEog_4A6wssWGT4mdsb5DQVWmRKnVT1tZcx0ld5doX24kUfj0OtwLBgtWMZr5zNKPTNO8IviIYy4-ZUylxiyltMVZEtuuL5px0UrWcY_Gy9qIOFVP0rLnI-QljKjCnr5sz1mHWUa3Om-V6gWmG4mNAcUDl0aG8BpdGn4u3CELxwxxGmBDY4hdf1g07eAvb2IdK9GiJydsY4EecHDpOc0bZpZJg8sEhGMGHXNCukr4HBHPy-U3zaoApu7fP9bL59uX6YXfb3t3ffN19vmstU6S0TlClhej2ou_3qgPNNeUD1o7j3rreSlAAoHupJcFqcFTuNWOyZz0D7jhjl82nk-9x3h-qwIXtLHNM_gBpNRG8-XsT_KMZ42I0p4QQXg0-PBuk-H12uZiDz9ZNEwQX52yoxFJJLuiGvv8HfYpzCvW9SjEllFKcVoqeKJtizskNv48h2GyxmlOspsZqfsVq1ipiJ1GucBhd-mP9H9VPVkGoGw</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Alanís-Ríos, Sergio A.</creator><creator>González, Gloria M.</creator><creator>Andrade, Angel</creator><creator>Becerril-García, Miguel A.</creator><creator>Bonifaz, Alexandro</creator><creator>Robledo-Leal, Efrén R.</creator><creator>Montoya, Alexandra M.</creator><creator>Treviño-Rangel, Rogelio de J.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221201</creationdate><title>Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris</title><author>Alanís-Ríos, Sergio A. ; González, Gloria M. ; Andrade, Angel ; Becerril-García, Miguel A. ; Bonifaz, Alexandro ; Robledo-Leal, Efrén R. ; Montoya, Alexandra M. ; Treviño-Rangel, Rogelio de J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-e5289556b5ddb86a94924f09e40dcedc7a8aaa9d797108fe27b9337d3d3a4e433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antagonism</topic><topic>Antidepressants</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Biomedical and Life Sciences</topic><topic>Candida auris</topic><topic>Clinical isolates</topic><topic>Clinical Microbiology - Short Communication</topic><topic>Food Microbiology</topic><topic>Fungal infections</topic><topic>Fungicides</topic><topic>Health risks</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Micafungin</topic><topic>Microbial Ecology</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Mycology</topic><topic>Public health</topic><topic>Sertraline</topic><topic>Voriconazole</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alanís-Ríos, Sergio A.</creatorcontrib><creatorcontrib>González, Gloria M.</creatorcontrib><creatorcontrib>Andrade, Angel</creatorcontrib><creatorcontrib>Becerril-García, Miguel A.</creatorcontrib><creatorcontrib>Bonifaz, Alexandro</creatorcontrib><creatorcontrib>Robledo-Leal, Efrén R.</creatorcontrib><creatorcontrib>Montoya, Alexandra M.</creatorcontrib><creatorcontrib>Treviño-Rangel, Rogelio de J.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brazilian journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alanís-Ríos, Sergio A.</au><au>González, Gloria M.</au><au>Andrade, Angel</au><au>Becerril-García, Miguel A.</au><au>Bonifaz, Alexandro</au><au>Robledo-Leal, Efrén R.</au><au>Montoya, Alexandra M.</au><au>Treviño-Rangel, Rogelio de J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris</atitle><jtitle>Brazilian journal of microbiology</jtitle><stitle>Braz J Microbiol</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>53</volume><issue>4</issue><spage>2003</spage><epage>2008</epage><pages>2003-2008</pages><issn>1517-8382</issn><eissn>1678-4405</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Responsible Editor: Luiz Henrique Rosa</notes><abstract>Candida auris
is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of
C. auris
. Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indifferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating
C. auris
infections.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36036298</pmid><doi>10.1007/s42770-022-00817-y</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Brazilian journal of microbiology, 2022-12, Vol.53 (4), p.2003-2008 |
| issn | 1517-8382 1678-4405 |
| language | eng |
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| source | Springer Link; PubMed Central |
| subjects | Antagonism Antidepressants Antifungal activity Antifungal agents Biomedical and Life Sciences Candida auris Clinical isolates Clinical Microbiology - Short Communication Food Microbiology Fungal infections Fungicides Health risks Life Sciences Medical Microbiology Micafungin Microbial Ecology Microbial Genetics and Genomics Microbiology Mycology Public health Sertraline Voriconazole Yeasts |
| title | Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris |
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