Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris

Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a fea...

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Bibliographic Details
Published in:Brazilian journal of microbiology 2022-12, Vol.53 (4), p.2003-2008
Main Authors: Alanís-Ríos, Sergio A., González, Gloria M., Andrade, Angel, Becerril-García, Miguel A., Bonifaz, Alexandro, Robledo-Leal, Efrén R., Montoya, Alexandra M., Treviño-Rangel, Rogelio de J.
Format: Article
Language:English
Subjects:
Antagonism
Antidepressants
Antifungal activity
Antifungal agents
Biomedical and Life Sciences
Candida auris
Clinical isolates
Clinical Microbiology - Short Communication
Food Microbiology
Fungal infections
Fungicides
Health risks
Life Sciences
Medical Microbiology
Micafungin
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Mycology
Public health
Sertraline
Voriconazole
Yeasts
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Summary:Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of C. auris . Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indifferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating C. auris infections.
ISSN:1517-8382
1678-4405
DOI:10.1007/s42770-022-00817-y