COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity

Purpose This study aims to evaluate the correlations between the severity of the disease and serum steroid levels by analyzing the serum steroid levels in COVID-19 patients with different levels of disease progression and the control group. Methods Morning serum Aldosterone, 11-deoxycortisol, Andros...

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Bibliographic Details
Published in:Endocrine 2022-11, Vol.78 (2), p.373-379
Main Authors: Sezer, Sevilay, Bal, Ceylan, Kalem, Ayşe Kaya, Kayaaslan, Bircan, Eser, Fatma, Hasanoglu, İmran, Akıncı, Esragül, Güner, Rahmet, Erel, Özcan, Yılmaz, Gülsen
Format: Article
Language:English
Subjects:
17β-Estradiol
Aldosterone
Androstenedione
Coronaviruses
Corticosterone
COVID-19
Dehydroepiandrosterone
Dehydroepiandrosterone sulfate
Diabetes
Dihydrotestosterone
Endocrinology
Estrone
Humanities and Social Sciences
Internal Medicine
Liquid chromatography
Medicine
Medicine & Public Health
multidisciplinary
Original
Original Article
Pregnenolone
Progesterone
Science
Steroid hormones
Steroids
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Summary:Purpose This study aims to evaluate the correlations between the severity of the disease and serum steroid levels by analyzing the serum steroid levels in COVID-19 patients with different levels of disease progression and the control group. Methods Morning serum Aldosterone, 11-deoxycortisol, Androstenedione, 17-hydroxyprogesterone, Dihydrotestosterone (DHT), Dehydroepiandrosterone (DHEA), Corticosterone, Dehydroepiandrosterone sulfate (DHEAS), Estrone, Estradiol, Progesterone, 11-deoxycorticosterone, Cortisol, Corticosterone, Androsterone, Pregnenolone, 17-hydroxypregnenolone and 21-deoxycortisol levels were measured in 153 consecutive patients were grouped as mild, moderate, and severe based on the WHO COVID-19 disease severity classification and the control group. Steroid hormone levels were analyzed at once with a liquid chromatography-tandem mass spectrometric method (LC-MS/MS). Results In our study, nearly all steroids were statistically significantly higher in the patients’ group than in the control group ( p  
ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-022-03140-6