Label-Free Profiling of up to 200 Single-Cell Proteomes per Day Using a Dual-Column Nanoflow Liquid Chromatography Platform

Single-cell proteomics (SCP) has great potential to advance biomedical research and personalized medicine. The sensitivity of such measurements increases with low-flow separations (

Bibliographic Details

Published in:	Analytical chemistry (Washington) 2022-04, Vol.94 (15), p.6017-6025
Main Authors:	Webber, Kei G. I, Truong, Thy, Johnston, S. Madisyn, Zapata, Sebastian E, Liang, Yiran, Davis, Jacob M, Buttars, Alexander D, Smith, Fletcher B, Jones, Hailey E, Mahoney, Arianna C, Carson, Richard H, Nwosu, Andikan J, Heninger, Jacob L, Liyu, Andrey V, Nordin, Gregory P, Zhu, Ying, Kelly, Ryan T
Format:	Article
Language:	eng
Subjects:	cells Chromatography Chromatography, Liquid - methods Column chromatography Cycle protein Desalination HeLa Cells Humans INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Ionization Leukemia Liquid chromatography Low flow mass spectrometry Medical research Peptides Peptides - analysis peptides and proteins Pilot Projects Precision medicine protein identification Proteins Proteome - analysis Proteomes Proteomics proteomics, nanoPOTS Regeneration Subsystems Therapeutic targets Tumor cell lines
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