Analysis of the humoral and cellular response after the third COVID‐19 vaccination in patients with autoimmune hepatitis

Background & aims To explore the humoral and T‐cell response to the third COVID‐19 vaccination in autoimmune hepatitis (AIH). Methods Anti‐SARS‐CoV‐2 antibody titers were prospectively determined in 81 AIH patients and 53 healthy age‐ and sex‐matched controls >7 days (median 35) after the fir...

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Bibliographic Details
Published in:Liver international 2023-02, Vol.43 (2), p.393-400
Main Authors: Hartl, Johannes, Rüther, Darius Ferenc, Duengelhoef, Paul Maria, Brehm, Thomas Theo, Steinmann, Silja, Weltzsch, Jan Philipp, Glaser, Fabian, Sterneck, Martina, Sebode, Marcial, Weiler‐Normann, Christina, Lütgehetmann, Marc, Schaub, Golda Melina, Haag, Friedrich, Schramm, Christoph, Wiesch, Julian Schulze zur, Lohse, Ansgar Wilhelm
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Viral
autoimmune hepatitis
CD4 antigen
Complementary Therapies
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines
COVID‐19 vaccination
Hepatitis
Hepatitis, Autoimmune
Humans
Immune response
immunosuppression
Lymphocytes
Lymphocytes T
Original
Seroconversion
Severe acute respiratory syndrome coronavirus 2
Steroid hormones
Subgroups
Vaccination
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Summary:Background & aims To explore the humoral and T‐cell response to the third COVID‐19 vaccination in autoimmune hepatitis (AIH). Methods Anti‐SARS‐CoV‐2 antibody titers were prospectively determined in 81 AIH patients and 53 healthy age‐ and sex‐matched controls >7 days (median 35) after the first COVID‐19 booster vaccination. The spike‐specific T‐cell response was assessed using an activation‐induced marker assay (AIM) in a subset of patients. Results Median antibody levels were significantly lower in AIH compared to controls (10 908 vs. 25 000 AU/ml, p 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.15368