Relevant SARS‐CoV‐2 viremia is associated with COVID‐19 severity: Prospective cohort study and validation cohort

Early kinetics of SARS‐CoV‐2 viral load (VL) in plasma determined by quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) was evaluated as a predictor of poor clinical outcome in a prospective study and assessed in a retrospective validation cohort. Prospective observational single‐...

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Bibliographic Details
Published in:Journal of medical virology 2022-11, Vol.94 (11), p.5260-5270
Main Authors: Cardeñoso Domingo, Laura, Roy Vallejo, Emilia, Zurita Cruz, Nelly D., Chicot Llano, Marta, Ávalos Pérez‐Urria, Elena, Barrios, Ana, Hernando Santos, Julia, Ortiz, Javier, Rodríguez García, Sebastián C., Martín Ramírez, Alexandra, Ciudad Sañudo, Marianela, Marcos, Celeste, García Castillo, Elena, Fontán García‐Rodrigo, Leticia, González, Begoña, Méndez, Rosa, Iturrate, Isabel, Sanz García, Ancor, Villa, Almudena, Sánchez Azofra, Ana, Quicios, Begoña, Arribas, David, Álvarez Rodríguez, Jesús, Patiño, Pablo, Trigueros, Marina, Uriarte, Miren, Triguero Martínez, Ana, Arévalo, Cristina, Galván Román, José M., García‐Vicuña, Rosario, Ancochea, Julio, Soriano, Joan B., Canabal, Alfonso, Muñoz Calleja, Cecilia, De la Cámara, Rafael, Suarez Fernández, Carmen, González Álvaro, Isidoro, Rodríguez‐Serrano, Diego A.
Format: Article
Language:English
Subjects:
Adult
Cohort analysis
COVID-19
COVID-19 - diagnosis
disease severity
Hospitalization
Humans
Mortality
Patients
Polymerase chain reaction
poor outcome
Prospective Studies
Retrospective Studies
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viremia
Virology
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Summary:Early kinetics of SARS‐CoV‐2 viral load (VL) in plasma determined by quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) was evaluated as a predictor of poor clinical outcome in a prospective study and assessed in a retrospective validation cohort. Prospective observational single‐center study including consecutive adult patients hospitalized with COVID‐19 between November 2020 and January 2021. Serial plasma samples were obtained until discharge. Quantitative RT‐PCR was performed to assess SARS‐CoV‐2 VL. The main outcomes were in‐hospital mortality, admission to the Intensive Care Unit (ICU), and their combination (Poor Outcome). Relevant viremia (RV), established in the prospective study, was assessed in a retrospective cohort including hospitalized COVID‐19 patients from April 2021 to May 2022, in which plasma samples were collected according to clinical criteria. Prospective cohort: 57 patients were included. RV was defined as at least a twofold increase in VL within ≤2 days or a VL > 300 copies/ml, in the first week. Patients with RV (N = 14; 24.6%) were more likely to die than those without RV (35.7% vs. 0%), needed ICU admission (57% vs. 0%) or had Poor Outcome (71.4% vs. 0%), (p 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27989