Osteosarcoma mechanobiology and therapeutic targets

Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year survival rate of less than 20% after the development of metastases. Osteosarcoma is highly predisposed in Paget's disease of the bone, and both have common characteristic skeletal features due to rapid bone remode...

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Bibliographic Details
Published in:British journal of pharmacology 2022-01, Vol.179 (2), p.201-217
Main Authors: Shoaib, Zunaira, Fan, Timothy M., Irudayaraj, Joseph M. K.
Format: Article
Language:English
Subjects:
3D cell culture
Biophysics
bisphosphonates
Bone cancer
Bone Neoplasms - drug therapy
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Bone remodeling
bone remodelling
bone sarcoma
Bone tumors
Humans
mechanobiology
mechanotransduction
Medical prognosis
Metastases
Microenvironments
Osteitis Deformans
Osteosarcoma
Osteosarcoma - drug therapy
Osteosarcoma - metabolism
Osteosarcoma - pathology
Paget's disease
pharmacology
Review
Sarcoma
Therapeutic targets
therapy
Tumor Microenvironment
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Summary:Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year survival rate of less than 20% after the development of metastases. Osteosarcoma is highly predisposed in Paget's disease of the bone, and both have common characteristic skeletal features due to rapid bone remodelling. Osteosarcoma prognosis is location dependent, which further emphasizes the likely contribution of the bone microenvironment in its pathogenesis. Mechanobiology describes the processes involved when mechanical cues from the changing physical microenvironment of the bone are transduced to biological pathways through mechanosensitive cellular components. Mechanobiology‐driven therapies have been used to curb tumour progression by direct alteration of the physical microenvironment or inhibition of metastasis‐associated mechanosensitive proteins. This review emphasizes the contribution of mechanobiology to the progression of osteosarcoma and sheds light on current mechanobiology‐based therapies and potential new targets for improving disease management. Additionally, the many different 3D models currently used to study osteosarcoma mechanobiology are summarized.
ISSN:0007-1188
1476-5381
DOI:10.1111/bph.15713