“Commandeuring” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism

The understanding of how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determine the impact of the chemical and its metabolites to the (human) organism. This is part of the research and educational discipline ADMET (absorption, distribution, metabolism...

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Bibliographic Details
Published in:Chemical research in toxicology 2022-07, Vol.35 (7), p.1184-1201
Main Authors: van Vugt-Lussenburg, Barbara M. A., Capinha, Liliana, Reinen, Jelle, Rooseboom, Martijn, Kranendonk, Michel, Onderwater, Rob C. A., Jennings, Paul
Format: Article
Language:English
Subjects:
Review
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Summary:The understanding of how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determine the impact of the chemical and its metabolites to the (human) organism. This is part of the research and educational discipline ADMET (absorption, distribution, metabolism, elimination, and toxicity). Here, we review the work of Jan Commandeur and colleagues who have not only made a significant impact in understanding of phase I and phase II metabolism of several important compounds but also contributed greatly to the development of experimental techniques for the study of xenobiotic metabolism. Jan Commandeur’s work has covered a broad area of research, such as the development of online screening methodologies, the use of a combination of enzyme mutagenesis and molecular modeling for structure–activity relationship (SAR) studies, and the development of novel probe substrates. This work is the bedrock of current activities and brings the field closer to personalized (cohort-based) pharmacology, toxicology, and hazard/risk assessment.
ISSN:0893-228X
1520-5010
DOI:10.1021/acs.chemrestox.2c00067