Myasthenia gravis in pregnancy: Systematic review and case series

Background Myasthenia gravis is an autoimmune disease which can impact pregnancy. Methods Six databases were systematically searched for studies with at least five subjects reporting pregnancy outcomes for women with myasthenia gravis in pregnancy. Assessment of bias was performed for all included s...

Full description

Saved in:
Bibliographic Details
Published in:Obstetric medicine 2022-06, Vol.15 (2), p.108-117
Main Authors: Banner, Harrison, Niles, Kirsten M, Ryu, Michelle, Sermer, Mathew, Bril, Vera, Murphy, Kellie E
Format: Article
Language:English
Subjects:
Childbirth & labor
Clinical outcomes
Health risks
Myasthenia gravis
Obstetrics
Original
Perinatal care
Pregnancy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Myasthenia gravis is an autoimmune disease which can impact pregnancy. Methods Six databases were systematically searched for studies with at least five subjects reporting pregnancy outcomes for women with myasthenia gravis in pregnancy. Assessment of bias was performed for all included studies. Forty-eight cases from our own centre were also included in the analysis. Results In total, 32 publications met inclusion criteria for systematic review, for a total of 33 unique data sets including 48 cases from our institution. Outcome data was available for 824 pregnancies. Spontaneous vaginal delivery occurred in 56.3% of pregnancies. Overall risk of myasthenia gravis exacerbation was 33.8% with a 6.4% risk of myasthenic crisis in pregnancy and 8.2% postpartum. The incidence risk of transient neonatal myasthenia gravis was 13.0%. Conclusions The current systematic review provides the best estimates of risk currently available to aid in counselling women with myasthenia gravis in pregnancy.
ISSN:1753-495X
1753-4968
DOI:10.1177/1753495X211041899