Associations between steady-state pattern electroretinography and estimated retinal ganglion cell count in glaucoma suspects

Purpose To estimate retinal ganglion cell (RGC) count in glaucoma suspects (GS) and ascertain its relationships with steady-state pattern electroretinography (ssPERG) parameters. Methods In this prospective cross-sectional study, 22 subjects (44 eyes) were recruited at the Manhattan Eye, Ear, and Th...

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Bibliographic Details
Published in:Documenta ophthalmologica 2022-08, Vol.145 (1), p.11-25
Main Authors: Tirsi, Andrew, Orshan, Derek, Wong, Benny, Gliagias, Vasiliki, Tsai, Joby, Obstbaum, Stephen A., Tello, Celso
Format: Article
Language:English
Subjects:
Eye
Eye examinations
Glaucoma
Medicine
Medicine & Public Health
Ophthalmology
Original
Original Research Article
Retina
Retinal ganglion cells
Structure-function relationships
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Summary:Purpose To estimate retinal ganglion cell (RGC) count in glaucoma suspects (GS) and ascertain its relationships with steady-state pattern electroretinography (ssPERG) parameters. Methods In this prospective cross-sectional study, 22 subjects (44 eyes) were recruited at the Manhattan Eye, Ear, and Throat Hospital. Subjects underwent complete eye examinations, optical coherence tomography, standard automated perimetry, and ssPERG testing. Eyes were divided into two groups based upon clinical data: healthy subjects and GS. RGC count was estimated using the combined structure–function index. Results Estimated RGC count, average retinal nerve fiber layer thickness (ARNFLT), and average ganglion cell layer and inner plexiform layer thickness (GCIPLT) were reduced in GS eyes ( p  ≤  0.001 for all parameters). Pearson correlations revealed that ssPERG magnitude and magnitudeD correlated with ARNFLT (r  ≥  0.53, p    0.38, p    0.46, p  
ISSN:0012-4486
1573-2622
DOI:10.1007/s10633-022-09869-9