The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain

Purpose The composition of the subchondral bone marrow and cartilage endplate (CEP) could affect intervertebral disc health by influencing vertebral perfusion and nutrient diffusion. However, the relative contributions of these factors to disc degeneration in patients with chronic low back pain (cLB...

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Bibliographic Details
Published in:European spine journal 2022-07, Vol.31 (7), p.1866-1872
Main Authors: Bonnheim, Noah B., Wang, Linshanshan, Lazar, Ann A., Zhou, Jiamin, Chachad, Ravi, Sollmann, Nico, Guo, Xiaojie, Iriondo, Claudia, O’Neill, Conor, Lotz, Jeffrey C., Link, Thomas M., Krug, Roland, Fields, Aaron J.
Format: Article
Language:English
Subjects:
Age
Back pain
Bone composition
Bone marrow
Cartilage
Degeneration
Degenerative disc disease
Intervertebral discs
Low back pain
Magnetic resonance imaging
Medicine
Medicine & Public Health
Neurosurgery
Nucleus pulposus
Original
Original Article
Perfusion
Permeability
Proteoglycans
Regression analysis
Subchondral bone
Surgical Orthopedics
Vertebrae
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Summary:Purpose The composition of the subchondral bone marrow and cartilage endplate (CEP) could affect intervertebral disc health by influencing vertebral perfusion and nutrient diffusion. However, the relative contributions of these factors to disc degeneration in patients with chronic low back pain (cLBP) have not been quantified. The goal of this study was to use compositional biomarkers derived from quantitative MRI to establish how CEP composition (surrogate for permeability) and vertebral bone marrow fat fraction (BMFF, surrogate for perfusion) relate to disc degeneration. Methods MRI data from 60 patients with cLBP were included in this prospective observational study (28 female, 32 male; age = 40.0 ± 11.9 years, 19–65 [mean ± SD, min–max]). Ultra-short echo-time MRI was used to calculate CEP T2* relaxation times (reflecting biochemical composition), water-fat MRI was used to calculate vertebral BMFF, and T1ρ MRI was used to calculate T1ρ relaxation times in the nucleus pulposus (NP T1ρ, reflecting proteoglycan content and degenerative grade). Univariate linear regression was used to assess the independent effects of CEP T2* and vertebral BMFF on NP T1ρ. Mixed effects multivariable linear regression accounting for age, sex, and BMI was used to assess the combined relationship between variables . Results CEP T2* and vertebral BMFF were independently associated with NP T1ρ ( p  = 0.003 and 0.0001, respectively). After adjusting for age, sex, and BMI, NP T1ρ remained significantly associated with CEP T2* ( p  = 0.0001) but not vertebral BMFF ( p  = 0.43). Conclusion Poor CEP composition plays a significant role in disc degeneration severity and can affect disc health both with and without deficits in vertebral perfusion.
ISSN:0940-6719
1432-0932
DOI:10.1007/s00586-022-07206-x