Collateral Impact on Patients of Liver Diseases in the Second COVID-19 Wave: A Retrospective Cohort Study

BackgroundThe second wave of the COVID-19 pandemic in India started in April 2021. This necessitated a change in focus from chronic ailments. This wave lasted till May 2021. Its impact on liver disease patients without COVID-19 infection has not been analyzed.MethodsRecords of liver disease patients...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-05, Vol.14 (5), p.e25542-e25542
Main Authors: Vashishtha, Chitranshu, Bhardwaj, Ankit, Diwaker, Amita, Sharma, Shivakshi, Sharma, Manoj K, Sarin, Shiv
Format: Article
Language:English
Subjects:
Antigens
Cohort analysis
Coronaviruses
COVID-19
Creatinine
Etiology
Gastroenterology
Hemoglobin
Hepatitis B
Hepatitis C
Hospitals
Hypertension
Infections
Infectious Disease
Internal Medicine
Kidneys
Liver cancer
Liver diseases
Mortality
Pandemics
Transplants & implants
Variables
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundThe second wave of the COVID-19 pandemic in India started in April 2021. This necessitated a change in focus from chronic ailments. This wave lasted till May 2021. Its impact on liver disease patients without COVID-19 infection has not been analyzed.MethodsRecords of liver disease patients from the Institute database admitted from April to May 2021 were compared with that from April to May 2019 i.e., prior to the pandemic. The primary outcome was a comparison of in-hospital mortality rates. Secondary outcomes were a comparison of 30 and 90-day readmission rates and liver transplantation rates.ResultsSeven hundred and seventy-one patients in April-May 2019 (group 1) and 545 patients in April-May 2021 (group 2) were analyzed. Patients in group 2 were sicker with higher PT (INR), urea, creatinine, CTP, and MELD score and low serum sodium, albumin, and platelet count with a higher prevalence of variceal bleed, hepatic encephalopathy, and acute kidney injury. There was higher mortality in group 2 (128/545; 23.5%) than group 1 (124/ 771;16.1%), OR 1.6, 95% CI 1.2 - 2.1, p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.25542