A Modified Progressive Supranuclear Palsy Rating Scale for Virtual Assessments

Background The reliability of the Progressive Supranuclear Palsy Rating Scale (PSPRS) using teleneurology has not been assessed. Objectives To test whether removing items inadequately assessed by video would impact measurement of PSP severity and progression. Methods We performed secondary analyses...

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Bibliographic Details
Published in:Movement disorders 2022-06, Vol.37 (6), p.1265-1271
Main Authors: Wills, Anne‐Marie, Pantelyat, Alexander, Espay, Alberto, Chan, James, Litvan, Irene, Xie, Tao, Dale, Marian L., Gunzler, Steven A., Tartaglia, Maria Carmela, Fox, Susan H., Rodriguez‐Porcel, Federico, Sharma, Mansi, Lang, Anthony E., Boxer, Adam L., Golbe, Lawrence I.
Format: Article
Language:English
Subjects:
Agreements
Clinical Trials, Phase II as Topic
Clinical Trials, Phase III as Topic
Dystonia
Humans
Movement disorders
Paralysis
Progressive supranuclear palsy
PSP
PSPRS
Reproducibility of Results
Supranuclear Palsy, Progressive - diagnosis
Survival
Telemedicine
teleneurology
virtual
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Summary:Background The reliability of the Progressive Supranuclear Palsy Rating Scale (PSPRS) using teleneurology has not been assessed. Objectives To test whether removing items inadequately assessed by video would impact measurement of PSP severity and progression. Methods We performed secondary analyses of two data sets: the phase 2/3 trial of Davunetide in PSP and a large single‐center cohort. We examined two modifications of the PSPRS: (1) removing neck rigidity, limb rigidity, and postural stability (25 items; mPSPRS‐25) and (2) also removing three ocular motor items and limb dystonia (21 items; mPSPRS‐21). Proportional agreement relative to the possible total scores was measured using the intraclass correlation coefficient, compared to the original PSPRS baseline values and change over 6 and 12 months. We examined the ability of both scales to predict survival in the single‐center cohort using proportional hazards models. Results The mPSPRS‐25 showed excellent agreement (0.99; P 
ISSN:0885-3185
1531-8257
1531-8257
DOI:10.1002/mds.28991