A novel approach to studying early knee osteoarthritis illustrates that bilateral medial tibiofemoral osteoarthritis is a heritable phenotype: an offspring study

To assess the potential of studying offspring of people with and without knee osteoarthritis to understand the risk factors and heritability for knee osteoarthritis. We selected two groups of Osteoarthritis Initiative (OAI) participants from one clinical site: (1) participants with bilateral radiogr...

Full description

Saved in:
Bibliographic Details
Published in:Rheumatology international 2022-06, Vol.42 (6), p.1063-1072
Main Authors: Lo, Grace H., Richard, Michael J., Cauley, Jane A., Driban, Jeffrey B., Strayhorn, Michael, MacKay, James, Harkey, Matthew S., McAlindon, Timothy E., Jansen, Mary, Green, Stephanie, White, Donna L., Kwoh, C. Kent
Format: Article
Language:English
Subjects:
Arthritis
Disease Progression
Female
Humans
Knee
Knee Joint - diagnostic imaging
Knee Joint - pathology
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Observational Research
Osteoarthritis
Osteoarthritis, Knee - diagnostic imaging
Osteoarthritis, Knee - genetics
Phenotype
Radiography
Rheumatology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess the potential of studying offspring of people with and without knee osteoarthritis to understand the risk factors and heritability for knee osteoarthritis. We selected two groups of Osteoarthritis Initiative (OAI) participants from one clinical site: (1) participants with bilateral radiographic medial tibiofemoral osteoarthritis and (2) those without tibiofemoral osteoarthritis. We then invited biological offspring ≥ 18 years old to complete an online survey that inquired about osteoarthritis risk factors and symptoms. Among the survey respondents, we recruited ten offspring of members from each group for a clinic visit with bilateral knee posterior-anterior radiographs and magnetic resonance imaging of the right knee. We established contact with 269/413 (65%) eligible OAI participants. Most (227/269, 84%) had ≥ 1 eligible biological offspring, and 213 (94%) were willing to share information about the new family study with their offspring. Our survey was completed by 188 offspring from 110 OAI participants: mean age of 43.0 (10.4) years, mean body mass index of 23.7 (5.9) kg/m 2 , 65% female. Offspring obesity (OR = 2.7, 95% CI 1.0–7.3), hypertension (OR = 3.7, 95% CI 1.2–11.3), and Heberden’s nodes (OR = 3.6, 95% CI 1.0–13.2) were associated with parental osteoarthritis status; however, adjusted models were not statistically significant. Radiographic tibiofemoral osteoarthritis (16/18 knees vs. 2/20 knees) and meniscal abnormalities (7/9 vs. 2/10 index knees) were more common among offspring with parental osteoarthritis status than not. We established the potential of a novel offspring study design within the OAI, and our results are consistent with bilateral radiographic medial tibiofemoral osteoarthritis being a heritable phenotype of osteoarthritis.
ISSN:1437-160X
0172-8172
1437-160X
DOI:10.1007/s00296-022-05116-1