Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

Objective To compare AmnioQuick Duo+ versus the placental α‐microglobulin‐1 (PAMG‐1) test for diagnosis of prolonged premature rupture of membranes (PROM). Methods A multicenter prospective cohort study included women with suspected PROM at six tertiary institutions in southern Nigeria between Janua...

Full description

Saved in:
Bibliographic Details
Published in:International journal of gynecology and obstetrics 2019-02, Vol.144 (2), p.180-186
Main Authors: Eleje, George U., Ezugwu, Euzebus C., Ezebialu, Ifeanyichukwu U., Ojiegbe, Nnabuike O., Egeonu, Richard O., Obiora, Chukwudi C., Okafor, Chigozie G., Ikechebelu, Joseph I., Eke, Ahizechukwu C.
Format: Article
Language:English
Subjects:
Accuracy
Adolescent
Adult
alpha-Fetoproteins - analysis
AmnioQuick Duo
Biomarkers - analysis
Equivocal
Female
Fetal Membranes, Premature Rupture - diagnosis
Fetal Membranes, Premature Rupture - metabolism
Humans
Insulin-Like Growth Factor Binding Protein 1 - analysis
Middle Aged
Nigeria
PAMG‐1
Predictive Value of Tests
Pregnancy
Prolonged
PROM
Prospective Studies
Sensitivity and Specificity
Time Factors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To compare AmnioQuick Duo+ versus the placental α‐microglobulin‐1 (PAMG‐1) test for diagnosis of prolonged premature rupture of membranes (PROM). Methods A multicenter prospective cohort study included women with suspected PROM at six tertiary institutions in southern Nigeria between January 1 and December 31, 2015. The inclusion criteria were features of PROM lasting at least 24 hours and a pregnancy duration of more than 24 weeks. AmnioQuick Duo+ (Biosynex, Strasbourg, France) and PAMG‐1 (AmniSure International, Boston, USA) tests were used to diagnose PROM, which was confirmed after delivery by any two of the following criteria: delivery within 48 hours to 7 days, chorioamnionitis, membranes perceptibly ruptured at delivery, and adverse perinatal outcomes considerably associated with prolonged PROM. Results Of 100 women assessed for eligibility, 99 were included. Sensitivity, specificity, and accuracy were, respectively, 97.3%, 100%, and 95.9% for AmnioQuick Duo+, and 93.2%, 100%, and 90.4% for PAMG‐1. The differences were not significant and the diagnostic discordant rate between the two tests was 3.1%. In equivocal cases (i.e., negative pooling test result), AmnioQuick Duo+ and PAMG‐1 performed equally (diagnostic accuracy, 100% vs 97.7%; P>0.99). Conclusion For diagnosis of PROM, AmnioQuick Duo+ was found to be non‐inferior and comparable in accuracy to the PAMG‐1 test, with a diagnostic discordance rate of 3.1%. AmnioQuick Duo+ test was found to be non‐inferior and comparable to the PAMG‐1 test in the diagnosis of prolonged premature rupture of membranes.
ISSN:0020-7292
1879-3479
DOI:10.1002/ijgo.12703