Reasons for optimism in the search for new vaccines for tuberculosis

In the development of vaccines for tuberculosis (TB), the combination of the will, funding, scientific rigor, new tools, refined animal models and improved clinical trial designs are all converging at an opportune moment. The lack of optimism that has surrounded the likelihood for finding novel TB v...

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Bibliographic Details
Published in:Epidemiology and infection 2017-07, Vol.145 (9), p.1750-1756
Main Author: EVANS, T. G.
Format: Article
Language:English
Subjects:
Animal models
Drug delivery systems
Drug dosages
HIV
Human immunodeficiency virus
Humans
Immunology
Incidence
Infections
Infectious diseases
Intervention
Low income groups
Mortality
Mycobacterium tuberculosis - immunology
Pessimism
Product development
Review
REVIEW ARTICLE
Science
Tuberculosis
Tuberculosis - prevention & control
Tuberculosis Vaccines - immunology
Vaccination - trends
Vaccines
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Summary:In the development of vaccines for tuberculosis (TB), the combination of the will, funding, scientific rigor, new tools, refined animal models and improved clinical trial designs are all converging at an opportune moment. The lack of optimism that has surrounded the likelihood for finding novel TB vaccines has resulted from a lack of correlates of vaccine-induced protection, a lack of tool candidate vaccines to probe the immunologic space, which may be needed, and the negative result of one recent trial. A vaccine for TB that can be delivered at a reasonable cost to the marketplace will have greater impact on the incidence of new cases of TB than any intervention in world history. Now is the time to increase resources, both financial and human intellectual capacity, for a global tuberculosis vaccine effort.
ISSN:0950-2688
1469-4409
DOI:10.1017/S095026881700067X