Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir

A 66-year-old man, who had undergone plasma exchange 30 years previously in Egypt for the treatment of falciparum malaria, was referred to our hospital for treatment of chronic hepatitis C (HCV). An analysis of the 655-nucleotide 5′-untranslated region-core region sequence revealed infection with HC...

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Bibliographic Details
Published in:Internal Medicine 2022/05/15, Vol.61(10), pp.1537-1543
Main Authors: Hatanaka, Takeshi, Kakizaki, Satoru, Kaburagi, Takuya, Saito, Naoto, Nakano, Sachi, Hazama, Yoichi, Yoshida, Sachiko, Hachisu, Yoko, Tanaka, Yoshiki, Yoshinaga, Teruo, Kashiwabara, Kenji, Naganuma, Atsushi, Yamazaki, Yuichi, Uraoka, Toshio, Nagashima, Shigeo, Takahashi, Masaharu, Nishizawa, Tsutomu, Murata, Kazumoto, Okamoto, Hiroaki
Format: Article
Language:English
Subjects:
5' Untranslated Regions
Aged
Aminoisobutyric Acids
Antiviral Agents - therapeutic use
Benzimidazoles
Case Report
Chronic infection
Cyclopropanes
Drug Combinations
Genomes
Genotype
glecaprevir/pibrentasvir
Hepacivirus - genetics
Hepatitis C
hepatitis C virus
Hepatitis C, Chronic - drug therapy
Humans
Internal medicine
Japan
Lactams, Macrocyclic
Leucine - analogs & derivatives
Malaria
Male
Patients
Persistent Infection
Phylogeny
Proline - analogs & derivatives
Pyrrolidines - therapeutic use
Quinoxalines - therapeutic use
subtype 1g
Sulfonamides
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Summary:A 66-year-old man, who had undergone plasma exchange 30 years previously in Egypt for the treatment of falciparum malaria, was referred to our hospital for treatment of chronic hepatitis C (HCV). An analysis of the 655-nucleotide 5′-untranslated region-core region sequence revealed infection with HCV subtype 1g. A phylogenetic analysis of the full-length HCV genome confirmed that the patient's HCV was subtype 1g, which was the first case identified in Japan. Although his HCV possessed several naturally occurring resistance-associated substitutions in the nonstructural (NS) 3 and NS5A regions, he was successfully treated by combination therapy with glecaprevir/pibrentasvir.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8673-21