Volumetric Measurement of Relative CBV Using T1-Perfusion-Weighted MRI with High Temporal Resolution Compared with Traditional T2-Perfusion-Weighted MRI in Postoperative Patients with High-Grade Gliomas

T1-PWI with high temporal resolution may provide a reliable relative CBV value as a valid alternative to T2*-PWI under increased susceptibility. The purpose of this study was to assess the technical and clinical performance of T1-relative CBV in patients with postoperative high-grade gliomas. Forty-...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2022-06, Vol.43 (6), p.864-871
Main Authors: Seo, M, Ahn, K-J, Choi, Y, Shin, N-Y, Jang, J, Kim, B-S
Format: Article
Language:English
Subjects:
Adult Brain
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Functional
Glioma - diagnostic imaging
Glioma - pathology
Glioma - surgery
Humans
Magnetic Resonance Angiography
Magnetic Resonance Imaging - methods
Perfusion
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Summary:T1-PWI with high temporal resolution may provide a reliable relative CBV value as a valid alternative to T2*-PWI under increased susceptibility. The purpose of this study was to assess the technical and clinical performance of T1-relative CBV in patients with postoperative high-grade gliomas. Forty-five MRIs of 34 patients with proved high-grade gliomas were included. In all MRIs, T1- and T2*-PWIs were both acquired and processed semiautomatically to generate relative CBV maps using a released commercial software. Lesion masks were overlaid on the relative CBV maps, followed by a histogram of the whole VOI. The intraclass correlation coefficient and Bland-Altman plots were used for quantitative and qualitative comparisons. Signal loss from both methods was compared using the Wilcoxon signed-rank test of zero voxel percentage. The MRIs were divided into a progression group ( = 20) and a nonprogression group ( = 14) for receiver operating characteristic curve analysis. Fair intertechnique consistency was observed between the 90th percentiles of the T1- and T2*-relative CBV values (intraclass correlation coefficient = 0.558, < .001). T2*-PWI revealed a significantly higher percentage of near-zero voxels than T1-PWI (17.7% versus 3.1%, < .001). There was no statistically significant difference between the area under the curve of T1- and T2*-relative CBV (0.811 versus 0.793, = .835). T1-relative CBV showed 100% sensitivity and 57.1% specificity for the detection of progressive lesions. T1-relative CBV demonstrated exquisite diagnostic performance for detecting progressive lesions in postoperative patients with high-grade gliomas, suggesting the potential role of T1-PWI as a valid alternative to the traditional T2*-PWI.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A7527