ATRT-22. Outcomes for children with recurrent atypical teratoid rhabdoid tumor: A single institution study with updated molecular and germline analysis

Abstract BACKGROUND: Children with recurrent atypical teratoid rhabdoid tumor (recATRT) who fail frontline therapies have dismal outcomes. The association of ATRT molecular groups (SHH, TYR and MYC) and presence of underlying cancer predisposition with survival post-recurrence (postRD) is unknown. M...

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Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2022-06, Vol.24 (Supplement_1), p.i8-i8
Main Authors: Carey, Steven S, Huang, Jie, Myers, Jason R, Mostafavi, Roya, Orr, Brent, Michalik, Layna H, Klimo, Paul, Boop, Frederick, Nichols, Kim E, Merchant, Thomas, Ellison, David W, Robinson, Giles W, Onar-Thomas, Arzu, Gajjar, Amar, Upadhyaya, Santhosh
Format: Article
Language:English
Subjects:
Atypical Teratoid Rhabdoid Tumor
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Summary:Abstract BACKGROUND: Children with recurrent atypical teratoid rhabdoid tumor (recATRT) who fail frontline therapies have dismal outcomes. The association of ATRT molecular groups (SHH, TYR and MYC) and presence of underlying cancer predisposition with survival post-recurrence (postRD) is unknown. METHODS: We previously reported outcomes from a single-institution retrospective study of children
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/noac079.021