Clinical and molecular epidemiology of community-onset invasive Staphylococcus aureus infection in New Zealand children

Our aim was to describe the epidemiology and incidence of community-onset invasive S. aureus disease in children presenting to our hospital, and to compare the clonal complexes and virulence genes of S. aureus strains causing invasive and non-invasive disease. The virulence gene repertoire of invasi...

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Bibliographic Details
Published in:Epidemiology and infection 2014-08, Vol.142 (8), p.1713-1721
Main Authors: WILLIAMSON, D. A., RITCHIE, S. R., ROBERTS, S. A., COOMBS, G. W., THOMAS, M. G., HANNAFORD, O., BAKER, M. G., LENNON, D., FRASER, J. D.
Format: Article
Language:English
Subjects:
Adolescent
Antimicrobial agents
Bacteriology
Biological and medical sciences
Child
Child, Preschool
Cluster Analysis
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Community-Acquired Infections - pathology
Cross-Sectional Studies
Epidemiology
Ethnicity
Fundamental and applied biological sciences. Psychology
Genotype
Humans
Incidence
Infant
Infant, Newborn
Infections
Infectious diseases
Methicillin resistant staphylococcus aureus
Microarray Analysis
Microbiology
Miscellaneous
Molecular Epidemiology
Molecular Typing
New Zealand - epidemiology
Original Papers
Patients
Pediatrics
Population
Retrospective Studies
Skin
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal Infections - pathology
Staphylococci
Staphylococcus aureus
Staphylococcus aureus - classification
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
Staphylococcus infections
Statistical analysis
Variance analysis
Virulence
Virulence Factors - genetics
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Summary:Our aim was to describe the epidemiology and incidence of community-onset invasive S. aureus disease in children presenting to our hospital, and to compare the clonal complexes and virulence genes of S. aureus strains causing invasive and non-invasive disease. The virulence gene repertoire of invasive disease isolates was characterized using DNA microarray and compared with the virulence gene repertoire of non-invasive S. aureus isolates. Over the study period, 163 children had an invasive S. aureus infection. There was no difference in the distribution of clonal complexes or in the prevalence of genes encoding virulence factors between invasive and non-invasive isolates. Future research should include a strong focus on identifying the host and environmental factors that, along with organism virulence factors, are contributing to the patterns of invasive S. aureus disease observed in New Zealand.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268814000053