Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Objective. This study aimed to investigate the effects of gallic acid and silymarin against nephrotoxicity and hepatotoxicity caused by cisplatin. Materials and Methods. In the study, 56 Wistar Albino rats were equally divided into eight groups. Group 1 was the control group; group 2 was the group r...

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Published in:International journal of clinical practice (Esher) 2022, Vol.2022, p.6541026-10
Main Authors: Doğan, Duygu, Meydan, İsmet, Kömüroğlu, Ahmet Ufuk
Format: Article
Language:English
Subjects:
Acids
Antioxidants
Cisplatin
Creatinine
Deoxyguanosine
Enzymes
Free radicals
Gallic acid
Globulins
Glutathione
Hepatotoxicity
Ketamine
Kidneys
Liver
Oxidative stress
Silymarin
Statistical analysis
Superoxide dismutase
Toxicity
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Summary:Objective. This study aimed to investigate the effects of gallic acid and silymarin against nephrotoxicity and hepatotoxicity caused by cisplatin. Materials and Methods. In the study, 56 Wistar Albino rats were equally divided into eight groups. Group 1 was the control group; group 2 was the group receiving cisplatin; group 3 was the group receiving cisplatin + gallic acid; group 4 was the group receiving cisplatin + silymarin; group 5 was the group receiving cisplatin + silymarin + gallic acid; group 6 was the group receiving silymarin; group 7 was the group receiving gallic acid; group 8 was the group receiving gallic acid + silymarin. AST, ALT, urea, creatinine, albumin, globulin, and total protein levels were measured at the end of the study. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), and 8-hydroxy-2′-deoxyguanosine (8OH-dG) levels were measured in kidney and liver tissues. Additionally, histopathological evaluations of the tissues were also performed. Results. In kidney and liver tissues, cisplatin significantly increased MDA and 8-OHdG levels compared with treatment groups (p
ISSN:1368-5031
1742-1241
DOI:10.1155/2022/6541026