Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2

Alzheimer's disease (AD) is a genetically complex disease for which nearly 40 loci have now been identified via genome-wide association studies (GWAS). We attempted to identify groups of rare variants (alternate allele frequency

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Bibliographic Details
Published in:Molecular psychiatry 2022-04, Vol.27 (4), p.1963-1969
Main Authors: Prokopenko, Dmitry, Lee, Sanghun, Hecker, Julian, Mullin, Kristina, Morgan, Sarah, Katsumata, Yuriko, Weiner, Michael W, Fardo, David W, Laird, Nan, Bertram, Lars, Hide, Winston, Lange, Christoph, Tanzi, Rudolph E
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Alzheimer's disease
Dithionitrobenzoic Acid
Dystrophin-Associated Proteins - genetics
Gene frequency
Genes
Genetic Predisposition to Disease - genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomic analysis
Genomics
Guanylate Kinases - genetics
Humans
Neurodegenerative diseases
Neuropeptides - genetics
Polymorphism, Single Nucleotide - genetics
Postsynaptic density proteins
Tumor Suppressor Proteins - genetics
Whole Genome Sequencing
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Description
Summary:Alzheimer's disease (AD) is a genetically complex disease for which nearly 40 loci have now been identified via genome-wide association studies (GWAS). We attempted to identify groups of rare variants (alternate allele frequency
ISSN:1359-4184
1476-5578
DOI:10.1038/s41380-022-01475-0