Outcomes of adolescents and young adults with chronic-phase chronic myeloid leukaemia treated with tyrosine kinase inhibitors

Few studies have reported the outcomes of adolescents and young adults (AYAs) with chronic-phase chronic myeloid leukaemia (CML-CP) on tyrosine kinase inhibitors (TKIs). We retrospectively analysed the clinical features, treatment response, and long-term outcomes of 42 AYA patients, in comparison to...

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Bibliographic Details
Published in:Annals of medicine (Helsinki) 2022-12, Vol.54 (1), p.1244-1254
Main Authors: Nishiyama-Fujita, Yuriko, Nakazato, Tomonori, Iriyama, Noriyoshi, Tokuhira, Michihide, Ishikawa, Maho, Sato, Eriko, Takaku, Tomoiku, Sugimoto, Keiji, Fujita, Hiroyuki, Fujioka, Isao, Tsuchiya, Shun, Kimura, Yuta, Iwanaga, Eisaku, Komatsu, Norio, Asou, Norio, Kizaki, Masahiro, Hatta, Yoshihiro, Kawaguchi, Tatsuya
Format: Article
Language:English
Subjects:
Adolescent
adolescents and young adults
Chronic phase chronic myeloid leukaemia
Clinical Study
Dasatinib
Hematology
Humans
Imatinib Mesylate - adverse effects
Imatinib Mesylate - therapeutic use
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Leukemia, Myeloid, Chronic-Phase - diagnosis
Leukemia, Myeloid, Chronic-Phase - drug therapy
Nilotinib
Protein Kinase Inhibitors - adverse effects
Protein Kinase Inhibitors - therapeutic use
Retrospective Studies
tyrosine kinase inhibitors
Young Adult
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Summary:Few studies have reported the outcomes of adolescents and young adults (AYAs) with chronic-phase chronic myeloid leukaemia (CML-CP) on tyrosine kinase inhibitors (TKIs). We retrospectively analysed the clinical features, treatment response, and long-term outcomes of 42 AYA patients, in comparison to older patients. The initial therapies of AYA patients between 2001 and 2016 included imatinib (n = 24), dasatinib (n = 13) and nilotinib (n = 5). In AYA patients, the peripheral blood (PB) white blood cell count and percentage of blasts at the diagnosis were significantly higher, haemoglobin levels were lower and the spleen size was larger. The major molecular response (MMR), event-free survival (EFS) and overall survival (OS) rates were comparable. A sub-analysis comparing imatinib to second-generation TKIs as the initial therapy also showed that their prognosis was comparable. In conclusion, the tumour burden at the diagnosis of CML-CP is higher in AYA patients; however, their prognosis was not worse in comparison to older patients treated with TKIs. KEY MESSAGES Few studies have reported the outcomes of adolescents and young adults (AYAs) with chronic-phase chronic myeloid leukaemia (CML-CP) on tyrosine kinase inhibitors (TKIs). This study showed the tumour burden at the diagnosis of CML-CP is higher in AYA pa tients; however, their prognosis was not worse in comparison to older patients treated with TKIs. Understanding the biological and non-biological features of AYA patients with CML-CP on TKI therapy is essential for better management and to improve the outcomes.
ISSN:0785-3890
1365-2060
DOI:10.1080/07853890.2022.2069280