Different Indicators of Adiposity and Fat Distribution and Cardiometabolic Risk Factors in Patients with Type 2 Diabetes

Objective This study aimed to evaluate the effect of adiposity and fat distribution on the odds of elevated cardiovascular risk factors among adults with type 2 diabetes mellitus. Methods The present cross‐sectional study included 2,427 adults with type 2 diabetes mellitus. Body fat was assessed by...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2021-05, Vol.29 (5), p.837-845
Main Authors: Ding, Li, Fan, Yuxin, He, Jing, Wang, Ruodan, He, Qing, Cui, Jingqiu, Ma, Zhongshu, Zheng, Fangqiu, Gao, Hua, Dai, Chenlin, Wei, Hongyan, Li, Jun, Cao, Yuming, Hu, Gang, Liu, Ming
Format: Article
Language:English
Subjects:
Adiposity - physiology
Adult
Aged
Aged, 80 and over
Alcohol
Antihypertensives
Biochemistry
Blood pressure
Body composition
Body fat
Cardiometabolic Risk Factors
Cardiovascular disease
Cholesterol
Cross-Sectional Studies
Diabetes
Diabetes Mellitus, Type 2 - complications
Endocrinology
Family medical history
Female
Hemoglobin
Humans
Hypertension
Lipids
Low density lipoprotein
Male
Medical records
Metabolism
Middle Aged
Obesity
Obesity - physiopathology
Pelvis
Risk factors
Women
Young Adult
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Summary:Objective This study aimed to evaluate the effect of adiposity and fat distribution on the odds of elevated cardiovascular risk factors among adults with type 2 diabetes mellitus. Methods The present cross‐sectional study included 2,427 adults with type 2 diabetes mellitus. Body fat was assessed by dual‐energy x‐ray absorptiometry. Multivariate‐adjusted logistic regression was used to estimate effects of adiposity parameters on elevated hemoglobin A1c (HbA1c, ≥7.0%), hypertension (blood pressure ≥140/90 mmHg), and elevated low‐density lipoprotein (LDL) cholesterol (≥2.6 mmol/L). Results The multivariable‐adjusted odds ratio (OR) for elevated HbA1c was 0.82 (95% CI: 0.70‐0.96) for each SD increase in leg fat mass. The multivariable‐adjusted OR for hypertension was 1.15 (95% CI: 1.00‐1.32) for each SD increase in android fat mass. Multivariable‐adjusted ORs for elevated LDL cholesterol ranged from 1.16 (95% CI: 1.00‐1.35) to 1.27 (95% CI: 1.06‐1.51) for each SD increase in arm and android fat mass and percentage of total, truncal, arm, and android fat. Each SD increase in BMI, truncal‐to‐leg fat ratio, and android‐to‐gynoid fat ratio was significantly associated with increased risks of elevated HbA1c, hypertension, and elevated LDL cholesterol. Conclusions Subcutaneous fat in the lower body was associated with a more favorable glycemic profile, but not blood pressure or lipid profile, whereas central adiposity was associated with poor control of cardiovascular risk factors among patients with type 2 diabetes mellitus.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.23151