Synthesis of gamma radiation-induced PEGylated cisplatin for cancer treatment

The use of poly(ethylene glycol) (PEG) for the development of novel PEGylated biomolecules is playing an increasingly meaningful role in cancer treatment. Cisplatin (CDDP), is a useful chemotherapy drug. However, it is unclear whether PEGylated cisplatin (CDDPPEG) has potential as an alternative the...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (60), p.34718-34725
Main Authors: González Torres, Maykel, Cerna Cortez, Jorge, Balam Muñoz Soto, Rodrigo, Ríos Perez, Alfonso, Pfeiffer, Heriberto, Leyva Gómez, Gerardo, Zúñiga Ramos, Joaquín, Rivera, Ana Leonor
Format: Article
Language:English
Subjects:
Apoptosis
Biomolecules
Cancer
Cancer therapies
Cell cycle
Chemical compounds
Chemistry
Chemotherapy
Fourier transforms
Gamma rays
Pharmacology
Polyethylene glycol
Radiation effects
Scanning electron microscopy
Synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The use of poly(ethylene glycol) (PEG) for the development of novel PEGylated biomolecules is playing an increasingly meaningful role in cancer treatment. Cisplatin (CDDP), is a useful chemotherapy drug. However, it is unclear whether PEGylated cisplatin (CDDPPEG) has potential as an alternative therapeutic agent. Here we prepared a PEGylated cisplatin by gamma radiation-induced synthesis, for the first time. PEGylated drugs were characterized using Raman and Fourier transform infrared spectroscopy (FTIR), as well as scanning electron microscopy coupled with Energy Dispersive X-ray (SEM/EDX). The results show that the cisplatin can be successfully PEGylated by this method. Furthermore, we show a proposal for the mechanism of the PEGylation reaction. The novel product exhibits therapeutic potential comparable to cisplatin at concentrations lower than 23 μM (Pt), causing differences in cell cycle checkpoints, which suggest changes in the signaling pathways that control growth arrest and cause apoptosis of A549 cells.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra06296j