Heterocyclic iodoniums as versatile synthons to approach diversified polycyclic heteroarenes

Polycyclic heteroarenes are important scaffolds in the construction of pharmaceuticals. We have previously developed a series of novel heterocyclic iodoniums. In our current work, these unique iodoniums were employed to construct various complex polycyclic heteroarenes with structural diversity via...

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Bibliographic Details
Published in:RSC advances 2019-10, Vol.9 (57), p.3317-33179
Main Authors: Zhu, Daqian, Wu, Zhouming, Liang, Liyun, Sun, Yameng, Luo, Bingling, Huang, Peng, Wen, Shijun
Format: Article
Language:English
Subjects:
Chemistry
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Summary:Polycyclic heteroarenes are important scaffolds in the construction of pharmaceuticals. We have previously developed a series of novel heterocyclic iodoniums. In our current work, these unique iodoniums were employed to construct various complex polycyclic heteroarenes with structural diversity via tandem dual arylations. As a result, indole, thiophene and triphenylene motifs were fused into these heterocycles with high molecular quality, which might provide promising fragments in drug discovery. Moreover, these heterocycles could be diversified at a late stage. The transformation of heterocyclic iodoniums led to the construction of heterocycles with a high structural diversity.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra07288h