Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics

To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with d...

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Published in:JACC. Basic to translational science 2022-05, Vol.7 (5), p.425-441
Main Authors: Roh, Jason D, Kitchen, Robert R, Guseh, J Sawalla, McNeill, Jenna N, Aid, Malika, Martinot, Amanda J, Yu, Andy, Platt, Colin, Rhee, James, Weber, Brittany, Trager, Lena E, Hastings, Margaret H, Ducat, Sarah, Xia, Peng, Castro, Claire, Singh, Abhilasha, Atlason, Bjarni, Churchill, Timothy W, Di Carli, Marcelo F, Ellinor, Patrick T, Barouch, Dan H, Ho, Jennifer E, Rosenzweig, Anthony
Format: Article
Language:English
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Clinical Research
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Summary:To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFβ signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications.
ISSN:2452-302X
DOI:10.1016/j.jacbts.2022.01.013