Synthetic developmental biology: Engineering approaches to guide multicellular organization

Multicellular organisms of various complexities self-organize in nature. Organoids are in vitro 3D structures that display important aspects of the anatomy and physiology of their in vivo counterparts and that develop from pluripotent or tissue-specific stem cells through a self-organization process...

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Bibliographic Details
Published in:Stem cell reports 2022-04, Vol.17 (4), p.715-733
Main Authors: Zarkesh, Ibrahim, Kazemi Ashtiani, Mohammad, Shiri, Zahra, Aran, Saeideh, Braun, Thomas, Baharvand, Hossein
Format: Article
Language:English
Subjects:
Developmental Biology
engineering
organoid
Organoids
Review
self-organization
Stem Cells
Tissue Engineering
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Summary:Multicellular organisms of various complexities self-organize in nature. Organoids are in vitro 3D structures that display important aspects of the anatomy and physiology of their in vivo counterparts and that develop from pluripotent or tissue-specific stem cells through a self-organization process. In this review, we describe the multidisciplinary concept of “synthetic developmental biology” where engineering approaches are employed to guide multicellular organization in an experimental setting. We introduce a novel classification of engineering approaches based on the extent of microenvironmental manipulation applied to organoids. In the final section, we discuss how engineering tools might help overcome current limitations in organoid construction. In this article, Baharvand and colleagues describe synthetic developmental biology using a novel classification of engineering approaches based on the extent of microenvironmental manipulation applied to organoids
ISSN:2213-6711
2213-6711
DOI:10.1016/j.stemcr.2022.02.004