Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers

Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here, the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility. Human challenge participants were...

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Bibliographic Details
Published in:	Infection and immunity 2022-04, Vol.90 (4), p.e0038921-e0038921
Main Authors:	Barton, Amber, Hill, Jennifer, Bibi, Sagida, Chen, Liye, Jones, Claire, Jones, Elizabeth, Camara, Susana, Shrestha, Sonu, Jin, Celina, Gibani, Malick M, Dobinson, Hazel, Waddington, Claire, Darton, Thomas C, Blohmke, Christoph J, Pollard, Andrew J
Format:	Article
Language:	eng
Subjects:	Bacterial Infections Genetic Predisposition to Disease Healthy Volunteers Humans Immunology Paratyphoid Fever Salmonella enterica Salmonella paratyphi A Salmonella typhi Spotlight Selection Typhoid Fever - genetics
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Summary:	Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here, the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility. Human challenge participants were genotyped by Illumina OmniExpress-24 BeadChip array ( = 176) and/or transcriptionally profiled by RNA sequencing ( = 174). While the study was underpowered to detect any single nucleotide polymorphisms (SNPs) significant at the whole-genome level, two SNPs within and were identified with
ISSN:	0019-9567 1098-5522