Design parameters optimization of an electrothermal flow biosensor for the SARS-CoV-2 S protein immunoassay

To combat the coronavirus disease 2019 (COVID-19), great efforts have been made by scientists around the world to improve the performance of detection devices so that they can efficiently and quickly detect the virus responsible for this disease. In this context we performed 2D finite element simula...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of physics 2022-12, Vol.96 (14), p.4091-4101
Main Authors: Kaziz, Sameh, Ben Mariem, Ibrahim, Echouchene, Fraj, Gazzah, Mohamed Hichem, Belmabrouk, Hafedh
Format: Article
Language:English
Subjects:
Astrophysics and Astroparticles
Binding
Biosensors
Coronaviruses
COVID-19
Design optimization
Design parameters
Finite element method
Immunoassay
Microchannels
Original Paper
Performance enhancement
Physics
Physics and Astronomy
Proteins
Response time
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To combat the coronavirus disease 2019 (COVID-19), great efforts have been made by scientists around the world to improve the performance of detection devices so that they can efficiently and quickly detect the virus responsible for this disease. In this context we performed 2D finite element simulation on the kinetics of SARS-CoV-2 S protein binding reaction of a biosensor using the alternating current electrothermal (ACET) effect. The ACET flow can produce vortex patterns, thereby improving the transportation of the target analyte to the binding surface and thus enhancing the performance of the biosensor. Optimization of some design parameters concerning the microchannel height and the reaction surface, such as its length as well as its position on the top wall of the microchannel, in order to improve the biosensor efficiency, was studied. The results revealed that the detection time can be improved by 55% with an applied voltage of 10 V rms and an operating frequency of 150 kHz and that the decrease in the height of the microchannel and in the length of the binding surface can lead to an increase in the rate of the binding reaction and therefore decrease the biosensor response time. Also, moving the sensitive surface from an optimal position, located in front of the electrodes, decreases the performance of the device.
ISSN:0973-1458
0974-9845
DOI:10.1007/s12648-022-02360-w