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Physical activity and glioma: a case–control study with follow-up for survival
Purpose High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality. Methods We examined associations between lifetime physical activity and physical activity at different ages (15–18 years, 19–29 ye...
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Published in: | Cancer causes & control 2022-05, Vol.33 (5), p.749-757 |
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Main Authors: | , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Purpose
High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality.
Methods
We examined associations between lifetime physical activity and physical activity at different ages (15–18 years, 19–29 years, 30–39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case–control study (495 cases; 371 controls). We followed up cases over a median of 25 months to examine whether physical activity was associated with all-cause mortality. Physical activity and potential confounders were assessed by self-administered questionnaire. We examined associations between physical activity (metabolic equivalent [MET]-h/wk) and glioma risk using unconditional logistic regression and with all-cause mortality in cases using Cox regression.
Results
We noted a reduced risk of glioma for the highest (≥ 47 MET-h/wk) versus lowest ( |
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ISSN: | 0957-5243 1573-7225 |
DOI: | 10.1007/s10552-022-01559-w |