In vitro susceptibilities of 400 spanish isolates of Neisseria gonorrhoeae to gemifloxacin and 11 other antimicrobial agents

The in vitro activity of gemifloxacin versus those of 11 other antimicrobial agents against 400 strains of Neisseria gonorrhoeae was determined by microdilution with supplemented GC agar. A total of 37.5% of the strains were beta-lactamase positive. A total of 70 and 6.4% of the beta-lactamase-negat...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2000-09, Vol.44 (9), p.2543-2544
Main Authors: BERRON, S, VAZQUEZ, J. A, GIMENEZ, M. J, DE LA FUENTE, L, AGUILAR, L
Format: Article
Language:English
Subjects:
Analysis. Health state
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteriology
Biological and medical sciences
Epidemiology
Fluoroquinolones
Fundamental and applied biological sciences. Psychology
Gemifloxacin
General aspects
Humans
Medical sciences
Microbial Sensitivity Tests
Microbiology
Naphthyridines - pharmacology
Neisseria gonorrhoeae
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - isolation & purification
Penicillin Resistance
Pharmacology. Drug treatments
Public health. Hygiene
Public health. Hygiene-occupational medicine
Spain
Susceptibility
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Summary:The in vitro activity of gemifloxacin versus those of 11 other antimicrobial agents against 400 strains of Neisseria gonorrhoeae was determined by microdilution with supplemented GC agar. A total of 37.5% of the strains were beta-lactamase positive. A total of 70 and 6.4% of the beta-lactamase-negative strains exhibited intermediate and high-level penicillin resistance, respectively. Ceftriaxone and gemifloxacin were the most active drugs (MICs at which 90% of isolates are inhibited, 0.01 versus 0.007 microg/ml, respectively), with 100% of strains inhibited by 0.12 microg/ml.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.44.9.2543-2544.2000