Long-term high-dose l-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial

Purpose The current randomized, double-blind, placebo-controlled clinical trial addressed the effects on penile erectile function of relatively high daily oral doses (6 g/day) of l -ARG for 3 months ( N  = 51) compared to placebo ( N  = 47), in patients with vasculogenic ED, with comparison between...

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Published in:Journal of endocrinological investigation 2022-05, Vol.45 (5), p.941-961
Main Authors: Menafra, D., de Angelis, C., Garifalos, F., Mazzella, M., Galdiero, G., Piscopo, M., Castoro, M., Verde, N., Pivonello, C., Simeoli, C., Auriemma, R. S., Colao, A., Pivonello, R.
Format: Article
Language:English
Subjects:
Arginine
Arteries
Clinical trials
Dietary Supplements
Double-Blind Method
Double-blind studies
Endocrinology
Erectile dysfunction
Erectile Dysfunction - drug therapy
Flow velocity
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Original
Original Article
Patients
Penile Erection
Penis
Penis - blood supply
Placebos
Treatment Outcome
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Summary:Purpose The current randomized, double-blind, placebo-controlled clinical trial addressed the effects on penile erectile function of relatively high daily oral doses (6 g/day) of l -ARG for 3 months ( N  = 51) compared to placebo ( N  = 47), in patients with vasculogenic ED, with comparison between mild–moderate and severe vasculogenic ED. Methods The outcome measures included IIEF-6 score and cavernous arteries peak systolic flow velocity (PSV) at dynamic penile duplex ultrasonography (PDU). Results l -ARG supplementation for 3 months significantly increased IIEF-6 score in the overall cohort ( p  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-021-01704-3