Comment on "Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review" by R. Obaid, E. Mughal, N. Naeem, A. Sadiq, R. Alsantali, R. Jassas, Z. Moussa and S. Ahmed, RSC Advances , 2021, 11 , 22159

A review article has been published recently ( , 2021, , 22159-22198) describing flavonoids as inhibitors of tyrosinase. However, many compounds included in this review have been previously shown to act as substrates of this enzymes or antioxidants reducing tyrosinase-generated -quinones. Products o...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2022-02, Vol.12 (9), p.5395-5397
Main Author: Wojtasek, Hubert
Format: Article
Language:English
Subjects:
Antioxidants
Chemistry
Enzymes
Flavonoids
Inhibitors
Oxidation
Quinones
Spectrophotometry
Substrates
Tyrosinase
Tyrosine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A review article has been published recently ( , 2021, , 22159-22198) describing flavonoids as inhibitors of tyrosinase. However, many compounds included in this review have been previously shown to act as substrates of this enzymes or antioxidants reducing tyrosinase-generated -quinones. Products of their oxidation absorb light in a range different than dopachrome, the oxidation product of l-tyrosine or l-dopa, whose concentration is measured spectrophotometrically in the standard enzymatic assay to monitor the activity of this enzyme. This effect is interpreted as enzyme inhibition, which, in fact, is only apparent and results from inadequate methodology.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra08162d