Baseline Brain Function in the Pre-Adolescents of the ABCD Study

The Adolescent Brain Cognitive Development Study is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns...

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Bibliographic Details
Published in:Nature neuroscience 2021-06, Vol.24 (8), p.1176-1186
Main Authors: Hahn, S., Allgaier, N., Adise, S., Juliano, A.C., Yuan, D.K., Loso, H., Laurent, J., Hagler, D.J., Cornejo, M.D., Hatton, S., Agrawal, A., Aguinaldo, L., Aklin, W., Anokhin, A.P., Arroyo, J., Avenevoli, S., Banich, M.T., Bartsch, H., Bloch, M., Calabro, F.J., Calhoun, V., Clark, D.B., Constable, R.T., Constable, K., Corley, R., Cottler, L.B., Coxe, S., Do, E.K., Dosenbach, N.U.F., Fair, D.A., Feldstein-Ewing, S.W., Friedman-Hill, S., Galvan, A., Giedd, J., Glaser, P., Gray, K. M., Harms, M.P., Heeringa, S., Heitzeg, M.M., Hermosillo, R., Hettema, J.M., Hewitt, J.K., Hoffman, E., Huber, R.S., Huestis, M.A., Hyde, L.W., Jacobus, J., Karcher, N.R., Kaufman, A., Kelley, B., Kuperman, J., LeBlanc, K., Lever, N., Lisdahl, K., Little, A.R., Lopez, M., Luna, B., Madden, P.A., Mason, M.J., Matochik, J., McCandliss, B.D., Morgan, G., Mulford, C., Murray, P., Nagel, B.J., Neale, M.C., Neigh, G., Nencka, A., Noronha, A., Pariyadath, V., Paulus, M.P., Pelham, W.E., Pfefferbaum, D., Prouty, D., Puttler, L.I., Renshaw, P.F., Rojas, P., Ross, M. J., Sanchez, M., Schirda, C., Schloesser, D., Schulenberg, J., Sher, K.J., Simmons, W.K., Speer, N., Spittel, M., Sripada, C., Striley, C., Sutherland, M.T., Tanabe, J., Tapert, S.F., Thompson, W., Uban, K.A., Wing, D., Wolff-Hughes, D., Yang, R., Yurgelun-Todd, D.A., Zucker, R.A., Garavan, H.P.
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Language:eng
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Summary:The Adolescent Brain Cognitive Development Study is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from fMRI tasks completed at baseline, designed to measure cognitive impulse control with a Stop Signal task (n=5,547), reward anticipation and receipt with a Monetary Incentive Delay task (n=6,657), and working memory and emotion reactivity with an emotional N-back task (n=6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of BOLD activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlated with individual behavioral performance on the tasks. These results establish the pre-adolescent brain function baseline, guide interpretation of cross-sectional analyses, and will enable the investigation of longitudinal changes during adolescent development.
ISSN:1097-6256
1546-1726