Trans-cerebral HCO3− and PCO2 exchange during acute respiratory acidosis and exercise-induced metabolic acidosis in humans

This study investigated trans-cerebral internal jugular venous-arterial bicarbonate ([HCO3−]) and carbon dioxide tension (PCO2) exchange utilizing two separate interventions to induce acidosis: 1) acute respiratory acidosis via elevations in arterial PCO2 (PaCO2) (n = 39); and 2) metabolic acidosis...

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Bibliographic Details
Published in:	Journal of cerebral blood flow and metabolism 2022-04, Vol.42 (4), p.559-571
Main Authors:	Caldwell, Hannah G, Hoiland, Ryan L, Smith, Kurt J, Brassard, Patrice, Bain, Anthony R, Tymko, Michael M, Howe, Connor A, Carr, Jay MJR, Stacey, Benjamin S, Bailey, Damian M, Drapeau, Audrey, Sekhon, Mypinder S, MacLeod, David B, Ainslie, Philip N
Format:	Article
Language:	eng
Subjects:	Rapid Communications
Online Access:	Get full text
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Summary:	This study investigated trans-cerebral internal jugular venous-arterial bicarbonate ([HCO3−]) and carbon dioxide tension (PCO2) exchange utilizing two separate interventions to induce acidosis: 1) acute respiratory acidosis via elevations in arterial PCO2 (PaCO2) (n = 39); and 2) metabolic acidosis via incremental cycling exercise to exhaustion (n = 24). During respiratory acidosis, arterial [HCO3−] increased by 0.15 ± 0.05 mmol ⋅ l−1 per mmHg elevation in PaCO2 across a wide physiological range (35 to 60 mmHg PaCO2; P
ISSN:	0271-678X 1559-7016