Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials

This work describes the development of an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the determination of 23 primary aromatic amines (PAAs) that can potentially migrate from food contact materials. The chromatographic separation was performed in a...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2022-04, Vol.414 (9), p.3137-3151
Main Authors: Arrizabalaga-Larrañaga, Ane, de Juan-de Juan, Pedro, Bressan, Claudia, Vázquez-Espinosa, Mercedes, González-de-Peredo, Ana V., Santos, F. Javier, Moyano, Encarnación
Format: Article
Language:English
Subjects:
Acetic acid
Acetonitrile
Amines
Amines - analysis
Analysis
Analytical Chemistry
Aromatic amines
Atmospheric Pressure
Biochemistry
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chromatography
Chromatography, High Pressure Liquid - methods
Evaluation
Food
Food Science
High performance liquid chromatography
Ionization
Ions
Kitchenware
Laboratory Medicine
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Methods
Monitoring/Environmental Analysis
Nylons
Photoionization
Research Paper
Scientific imaging
Separation
Spectroscopy
Tandem Mass Spectrometry - methods
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Summary:This work describes the development of an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the determination of 23 primary aromatic amines (PAAs) that can potentially migrate from food contact materials. The chromatographic separation was performed in a pentafluorophenylpropyl (PFPP) column achieving the separation of all PAAs in less than 6.5 min using water to acetonitrile (0.1% acetic acid in both solvents) as mobile phase and a gradient elution. The feasibility of atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI) was evaluated as alternative to electrospray ionization (ESI) for the analysis of PAAs. Results showed that for most of the compounds, better responses were obtained with APCI, which shows the advantage of being less susceptible to matrix effects. Tandem mass spectrometry (MS/MS) fragmentation studies of [M + H] + allowed for the selection of the two most characteristic and abundant product ions of the 23 PAAs which led to the development of a selective and sensitive UHPLC-APCI-MS/MS method with limits of detection ranging from 0.2 to 2 μg kg −1 . Moreover, intra-day and inter-day precisions of the method in terms of relative standard deviation (RSD%) were lower than 10% and 15%, while trueness as relative error was 
ISSN:1618-2642
1618-2650
1618-2650
DOI:10.1007/s00216-022-03946-3