Long term changes to auditory sensitivity following blast trauma in mice
•Auditory sensitivity was measured before/after blasts in CBA/CaJ mice.•Sensitivity measured by behavioral and physiological tests decreased.•Thresholds, but not threshold shifts, were different across methods.•Longitudinal changes to hearing after a blast reflect damage to auditory periphery. Blast...
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| Published in: | Hearing research 2021-04, Vol.403, p.108201-108201, Article 108201 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | eng |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | •Auditory sensitivity was measured before/after blasts in CBA/CaJ mice.•Sensitivity measured by behavioral and physiological tests decreased.•Thresholds, but not threshold shifts, were different across methods.•Longitudinal changes to hearing after a blast reflect damage to auditory periphery.
Blast trauma is a common acoustic/physical insult occurring in modern warfare. Twenty percent of active duty military come into close proximity to explosions and experience mild to severe sensory deficits. The prevalence of such injuries is high but correlating auditory sensitivity changes with the initial insult is difficult because injury and evaluations are often separated by long time periods. Here, auditory sensitivity was measured before and after a traumatic blast in adult CBA/CaJ mice using auditory brainstem responses, distortion production otoacoustic emissions, and behavioral detection of pure tones. These measurements included baseline auditory sensitivity prior to injury in all mice, and again at 3, 30, and 90 days after the blast in the two physiological groups, and daily for up to 90 days in the behavioral group. Mice in all groups experienced an initial deterioration in auditory sensitivity, though physiological measurements showed evidence of recovery that behavioral measurements did not. Amplitudes and latencies of ABR waves may reflect additional changes beyond the peripheral damage shown by the threshold changes and should be explored further. The present work addresses a major gap in the current acoustic trauma literature both in terms of comparing physiological and behavioral methods, as well as measuring the time course of recovery. |
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| ISSN: | 0378-5955 1878-5891 |