Influence of reconstruction kernels on the accuracy of CT-derived fractional flow reserve

Influence of reconstruction kernels on the accuracy of CT-derived fractional flow reserve

Objectives We evaluated the influence of image reconstruction kernels on the diagnostic accuracy of CT-derived fractional flow reserve (FFR CT ) compared to invasive FFR in patients with coronary artery disease. Methods Sixty-nine patients, in whom coronary CT angiography was performed and who were...

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Bibliographic Details
Published in:European radiology 2022-04, Vol.32 (4), p.2604-2610
Main Authors: Ammon, Fabian, Moshage, Maximilian, Smolka, Silvia, Goeller, Markus, Bittner, Daniel O., Achenbach, Stephan, Marwan, Mohamed
Format: Article
Language:eng
Subjects:
Accuracy
Algorithms
Angiography
Cardiac
Cardiovascular disease
Computed tomography
Computed Tomography Angiography - methods
Coronary Angiography - methods
Coronary artery
Coronary artery disease
Coronary Artery Disease - diagnostic imaging
Coronary Stenosis - diagnostic imaging
Coronary Vessels
Data acquisition
Decision making
Diagnostic Radiology
Flow
Fractional Flow Reserve, Myocardial
Heart diseases
Humans
Image processing
Image reconstruction
Imaging
Internal Medicine
Interventional Radiology
Ischemia
Kernels
Lesions
Medical imaging
Medicine
Medicine & Public Health
Neuroradiology
Patients
Predictive Value of Tests
Radiology
Retrospective Studies
Sensitivity
Severity of Illness Index
Stenosis
Tomography, X-Ray Computed
Ultrasound
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Summary:Objectives We evaluated the influence of image reconstruction kernels on the diagnostic accuracy of CT-derived fractional flow reserve (FFR CT ) compared to invasive FFR in patients with coronary artery disease. Methods Sixty-nine patients, in whom coronary CT angiography was performed and who were further referred for invasive coronary angiography with FFR measurement via pressure wire, were retrospectively included. CT data sets were acquired using a third-generation dual-source CT system and rendered with medium smooth (Bv40) and sharp (Bv49) reconstruction kernels. FFR CT was calculated on-site using prototype software. Coronary stenoses with invasive FFR ≤ 0.80 were classified as significant. Agreement between FFR CT and invasive FFR was determined for both reconstruction kernels. Results One hundred analyzed vessels in 69 patients were included. Twenty-five vessels were significantly stenosed according to invasive FFR. Using a sharp reconstruction kernel for FFR CT resulted in a significantly higher correlation with invasive FFR ( r  = 0.74, p  
ISSN:0938-7994
1432-1084