Angiotensin II augments renal vascular smooth muscle sGC expression via an AT1R - FoxO transcription factor signaling axis

Renal artery stenosis causes elevated circulating Angiotensin II. This, in turn, leads to contraction and hypertrophy of smooth muscle and elevated blood pressure. Additionally, soluble guanylyl cyclase (sGC) expression and cGMP in the non-stenotic renal artery increases allowing for increased blood...

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Bibliographic Details
Published in:British journal of pharmacology 2021-06, Vol.179 (11), p.2490-2504
Main Authors: Galley, Joseph C., Hahn, Scott A., Miller, Megan P., Durgin, Brittany G., Jackson, Edwin K., Stocker, Sean D., Straub, Adam C.
Format: Article
Language:English
Online Access:Get full text
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Summary:Renal artery stenosis causes elevated circulating Angiotensin II. This, in turn, leads to contraction and hypertrophy of smooth muscle and elevated blood pressure. Additionally, soluble guanylyl cyclase (sGC) expression and cGMP in the non-stenotic renal artery increases allowing for increased blood flow to the healthy kidney.
ISSN:0007-1188
1476-5381
DOI:10.1111/bph.15522