Serial Assessment of Myocardial Injury Markers in Mechanically Ventilated Patients With SARS-CoV-2 (from the Prospective MaastrICCht Cohort)

Serial Assessment of Myocardial Injury Markers in Mechanically Ventilated Patients With SARS-CoV-2 (from the Prospective MaastrICCht Cohort)

Myocardial injury in COVID-19 is associated with in-hospital mortality. However, the development of myocardial injury over time and whether myocardial injury in patients with COVID-19 at the intensive care unit is associated with outcome is unclear. This study prospectively investigates myocardial i...

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Bibliographic Details
Published in:The American journal of cardiology 2022-05, Vol.170, p.118-127
Main Authors: Ghossein, Mohammed A., Driessen, Rob G.H., van Rosmalen, Frank, Sels, Jan-Willem E.M., Delnoij, Thijs, Geyik, Zafer, Mingels, Alma M.A., van Stipdonk, Antonius M.W., Prinzen, Frits W., Ghossein-Doha, Chahinda, van Kuijk, Sander M.J., van der Horst, Iwan C.C., Vernooy, Kevin, van Bussel, Bas C.T.
Format: Article
Language:eng
Subjects:
Abnormalities
Biomarkers
Brain natriuretic peptide
Calcium-binding protein
Coronaviruses
COVID-19
COVID-19 - epidemiology
Creatinine
Diabetes mellitus
Electrocardiography
Gender
Heart attacks
Heart failure
Hemodynamics
Humans
Hypertension
Injuries
Intensive care
Intubation
Markers
Medical research
Mortality
Natriuretic Peptide, Brain
Patients
Peptide Fragments
Prospective Studies
Respiration, Artificial
Risk factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Survival
Troponin
Troponin T
Ventilation
Ventilators
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Summary:Myocardial injury in COVID-19 is associated with in-hospital mortality. However, the development of myocardial injury over time and whether myocardial injury in patients with COVID-19 at the intensive care unit is associated with outcome is unclear. This study prospectively investigates myocardial injury with serial measurements over the full course of intensive care unit admission in mechanically ventilated patients with COVID-19. As part of the prospective Maastricht Intensive Care COVID cohort, predefined myocardial injury markers, including high-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and electrocardiographic characteristics were serially collected in mechanically ventilated patients with COVID-19. Linear mixed-effects regression was used to compare survivors with nonsurvivors, adjusting for gender, age, APACHE-II score, daily creatinine concentration, hypertension, diabetes mellitus, and obesity. In 90 patients, 57 (63%) were survivors and 33 (37%) nonsurvivors, and a total of 628 serial electrocardiograms, 1,565 hs-cTnT, and 1,559 NT-proBNP concentrations were assessed. Log-hs-cTnT was lower in survivors compared with nonsurvivors at day 1 (β −0.93 [−1.37; −0.49], p
ISSN:0002-9149
1879-1913