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A systematic review and meta-analysis of the accuracy of SARS-COV-2 IGM and IGG tests in individuals with COVID-19
•The study verified the IgM and IgG antibodies accuracy for SARS-CoV-2 infection.•Serological tests may have a role in complementing another testing for SARS-CoV-2.•Sensitivity and specificity for IgM and/or IgG were 80% and 97%, respectively.•IgM and IgG together had a high accuracy performance on...
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Published in: | Journal of clinical virology 2022-03, Vol.148, p.105121-105121, Article 105121 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •The study verified the IgM and IgG antibodies accuracy for SARS-CoV-2 infection.•Serological tests may have a role in complementing another testing for SARS-CoV-2.•Sensitivity and specificity for IgM and/or IgG were 80% and 97%, respectively.•IgM and IgG together had a high accuracy performance on the 15th day and after.
: Active SARS-CoV-2 infection is confirmed mainly through the detection of viral nucleic acid via the reverse transcriptase polymerase chain reaction (RT-PCR) technique. Methods to assess humoral responses contribute to the monitoring of the disease and confirmation of exposure to the virus.
: To evaluate the accuracy of tests for IgM and IgG antibodies for SARS-CoV-2 infection confirmed by RT-PCR and utility as complementary data for immunosurveillance.
: Literature research was performed by searching the terms “COVID-19”, “COVID-19 diagnostic testing” and “test” in the databases MEDLINE, EMBASE, Cochrane Library, Web of Science and Cumulative Index to Nursing and Allied Health Literature to search for potentially eligible observational studies without language restrictions published up to September 2020.
: The pooled sensitivity and specificity, regardless of collection moment, was 80.0% (CI 95% 72.0–86.0) and 97.0% (CI 95% 94.0–98.0) for “IgM and/or IgG”, respectively. Serology considering immunoglobulins M and G together had a high accuracy performance on “fifteenth day and after”: sensitivity and specificity was 91.0% (CI 95% 85.0–94.0) and 98.0% (CI 95% 95.0–99.0) respectively, DOR 461 and AUC 0.98.
: This study shows that serology is a group of tests with high accuracy, mainly following the second week after infection. |
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ISSN: | 1386-6532 1873-5967 |
DOI: | 10.1016/j.jcv.2022.105121 |