Longitudinal changes in vascular stiffness and heart rate variability among young adults with youth-onset type 2 diabetes: results from the follow-up observational treatment options for type 2 diabetes in adolescents and youth (TODAY) study

Aims (1) To describe changes in arterial stiffness and heart rate variability (HRV) over a 5-year interval, (2) examine changes by sex and race–ethnicity, and (3) evaluate the risk factors associated with the longitudinal changes in arterial stiffness and HRV. Methods Participants with youth-onset t...

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Bibliographic Details
Published in:Acta diabetologica 2022-02, Vol.59 (2), p.197-205
Main Authors: Shah, Amy S., El ghormli, Laure, Gidding, Samuel S., Hughan, Kara S., Levitt Katz, Lorraine E., Koren, Dorit, Tryggestad, Jeanie B., Bacha, Fida, Braffett, Barbara H., Arslanian, Silva, Urbina, Elaine M.
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adult
Blood pressure
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Ethnicity
Female
Follow-Up Studies
Heart Rate
Hemoglobin
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Minority & ethnic groups
Original Article
Parasympathetic nervous system
Pulse Wave Analysis
Regression analysis
Risk Factors
Vascular Stiffness
Velocity
Young Adult
Young adults
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Summary:Aims (1) To describe changes in arterial stiffness and heart rate variability (HRV) over a 5-year interval, (2) examine changes by sex and race–ethnicity, and (3) evaluate the risk factors associated with the longitudinal changes in arterial stiffness and HRV. Methods Participants with youth-onset type 2 diabetes enrolled in the observational follow-up phase of the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial had arterial stiffness [(pulse wave velocity, augmentation index, brachial distensibility] and six indices of HRV measured 5 years apart. Multivariable linear regression models assessed risk factors associated with changes in the outcomes over time. Results At initial vascular assessment, the 304 participants were a mean age of 21 years, 34% male, and had a mean diabetes duration of 8 years. In more than half the cohort pulse wave velocity, augmentation index and HRV increased over 5 years ( p
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-021-01796-6