Association between HLA alleles and sub-phenotype of childhood steroid-sensitive nephrotic syndrome

Background Few studies have addressed the effects of human leukocyte antigen (HLA) alleles on different clinical sub-phenotypes in childhood steroid-sensitive nephrotic syndrome (SSNS), including SSNS without recurrence (SSNSWR) and steroid-dependent nephrotic syndrome/frequently relapse nephrotic s...

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Published in:World journal of pediatrics : WJP 2022-02, Vol.18 (2), p.109-119
Main Authors: Lee, Hao, Wang, Li, Ni, Fen-Fen, Yang, Xue-Ying, Feng, Shi-Pin, Gao, Xiao-Jie, Chi, Huan, Luo, Ye-Tao, Chen, Xue-Lan, Yang, Bao-Hui, Wan, Jun-Li, Jiao, Jia, Wu, Dao-Qi, Zhang, Gao-Fu, Wang, Mo, Yang, Hai-Ping, Chan, Han, Li, Qiu
Format: Article
Language:English
Subjects:
Critical Care Medicine
Imaging
Intensive
Maternal and Child Health
Medicine
Medicine & Public Health
Original
Original Article
Pediatric Surgery
Pediatrics
Radiology
Surgery
Citations: Items that this one cites
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Summary:Background Few studies have addressed the effects of human leukocyte antigen (HLA) alleles on different clinical sub-phenotypes in childhood steroid-sensitive nephrotic syndrome (SSNS), including SSNS without recurrence (SSNSWR) and steroid-dependent nephrotic syndrome/frequently relapse nephrotic syndrome (SDNS/FRNS). In this study, we investigated the relationship between HLA system and children with SSNSWR and SDNS/FRNS and clarified the value of HLA allele detection for precise typing of childhood SSNS. Methods A total of 241 Chinese Han individuals with SSNS were genotyped using GenCap-WES Capture Kit, and four-digit resolution HLA alleles were imputed from available Genome Wide Association data. The distribution and carrying frequency of HLA alleles in SSNSWR and SDNS/FRNS were investigated. Additionally, logistic regression and mediating effects were used to examine the relationship between risk factors for disease process and HLA system. Results Compared with SSNSWR, significantly decreased serum levels of complement 3 (C3) and complement 4 (C4) at onset were detected in SDNS/FRNS (C3, P  
ISSN:1708-8569
1867-0687
DOI:10.1007/s12519-021-00489-y