The Influence of Diabetes Mellitus on the Risks of End-Stage Kidney Disease and Mortality After Liver Transplantation

This retrospective study aimed to investigate the effect of diabetes mellitus (DM) on the risks of end-stage kidney disease (ESKD) and post-liver transplantation (post-LT) mortality. Using data from the National Health Insurance Research Database, Taiwan, 3,489 patients who received a LT between 1 J...

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Bibliographic Details
Published in:Transplant international 2022-02, Vol.35, p.10023-10023
Main Authors: Lee, Chung-Ying, Wu, Mei-Yi, Chan, Hsiu-Chen, Chen, Tzu-Ting, Hsu, Le-Yin, Wu, Mai-Szu, Cherng, Yih-Giun
Format: Article
Language:English
Subjects:
Diabetes Mellitus
Health Archive
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - surgery
Liver Transplantation - adverse effects
Retrospective Studies
Risk Factors
Taiwan - epidemiology
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Summary:This retrospective study aimed to investigate the effect of diabetes mellitus (DM) on the risks of end-stage kidney disease (ESKD) and post-liver transplantation (post-LT) mortality. Using data from the National Health Insurance Research Database, Taiwan, 3,489 patients who received a LT between 1 January 2005, and 31 December 2015, were enrolled in this study and divided into the pre-existing DM, post-LT DM (PLTDM), and without DM groups. All subjects were followed up from 1 year after LT to the index date for ESKD, and the occurrence of death, or until 31 December 2016. Of the 3,489 patients with LT, 1,016 had pre-existing DM, 215 had PLTDM, and 2,258 had no DM pre- or post-LT. The adjusted HRs of ESKD were 1.77 (95% Confidence Interval [CI], .78-3.99) and 2.61 (95% CI, 1.63-4.18) for PLTDM group and pre-existing DM group compared to without DM group, respectively. For the risk of death, the adjusted HRs were 1.05 (95% CI, .72-1.55) and 1.28 (95% CI, 1.04-1.59) for PLTDM group and pre-existing DM group compared to those without DM group, respectively. The sensitivity analysis for the risk of ESKD and death also revealed the consistent result. Pre-existing DM has significant increase the risk of post-LT ESKD and mortality. The role of PLTDM should be explored to explain postoperative morbidity and mortality.
ISSN:1432-2277
0934-0874
1432-2277
DOI:10.3389/ti.2022.10023