Ocular Distribution of the Renin-Angiotensin-Aldosterone System in the Context of the SARS-CoV-2 Pandemic

The COVID-19 pandemic has resulted in an unprecedented impact on global health, economy, and way of life. SARS-CoV-2, the virus responsible for the disease, utilizes the ACE2 receptor found on host cells to mediate entry, replication, and infection. Numerous studies have elucidated the presence of m...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Renin-Angiotensin-Aldosterone System 2022-01, Vol.2022, p.9970922-9970922
Main Authors: Abid, Ali, Khan, Muhammad Azaan, Lee, Brendon, White, Andrew, Carnt, Nicole, Arshad, Sana, Samarawickrama, Chameen
Format: Article
Language:English
Subjects:
COVID-19
Disease transmission
Endocrine system
Eyes & eyesight
Humans
Pandemics
Pathogens
Renin-Angiotensin System
Review
SARS-CoV-2
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The COVID-19 pandemic has resulted in an unprecedented impact on global health, economy, and way of life. SARS-CoV-2, the virus responsible for the disease, utilizes the ACE2 receptor found on host cells to mediate entry, replication, and infection. Numerous studies have elucidated the presence of many components of the renin-angiotensin-aldosterone system (RAAS) in the eye, including the ACE2 receptor. Considering this, and the anatomical vulnerability that the exposed ocular surface offers with its interconnectedness to the respiratory system, there is a theoretical risk of pathogen entry from the ocular route as well as the development of COVID-19-associated eye disease. Despite this, the actual epidemiological data demonstrates low ocular symptoms, possibly due to differing ACE2 receptor expression across age, ethnicity, and sex coupled with the protective properties of tears. We summarize the current literature on ocular RAAS with specific focus on the ACE2 receptor and its interplay with the SARS-CoV-2 virus.
ISSN:1470-3203
1752-8976
DOI:10.1155/2022/9970922