Significance of preoperative blood tests in the prognosis of colorectal cancer: A prospective, multicenter study from Hungary

Background The focus of this study was to analyze the prognostic value of different combinations of inflammatory and coagulation factors using preoperative blood and to appraise the clinical importance of these biomarkers in colorectal cancer patients. Methods A prospective, multicenter study includ...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2022-01, Vol.36 (1), p.e24128-n/a
Main Authors: Biró, Adrienn, Kolozsi, Péter, Nagy, Attila, Varga, Zsolt, Káposztás, Zsolt, Tóth, Dezső
Format: Article
Language:English
Subjects:
biomarker
Biomarkers
Blood coagulation
Blood platelets
Blood tests
Body mass index
Cancer therapies
Chemotherapy
Clinical outcomes
Coagulation factors
Colon cancer
Colorectal cancer
Colorectal carcinoma
Ethics
Inflammation
Laboratories
laboratory
Laparoscopy
leukocyte
Leukocytes (neutrophilic)
Localization
Lymphocytes
Males
Medical prognosis
Metastases
Metastasis
Mortality
Multivariate analysis
neutrophil
Neutrophils
Patients
prognostic
Proteins
Rectum
Surgery
survival
Teaching hospitals
Thromboplastin
Tumors
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Summary:Background The focus of this study was to analyze the prognostic value of different combinations of inflammatory and coagulation factors using preoperative blood and to appraise the clinical importance of these biomarkers in colorectal cancer patients. Methods A prospective, multicenter study included patients undergoing radical colorectal surgery in three county hospitals. Inflammatory and coagulation markers were analyzed preoperatively. Results Two hundred and one patients were included. We examined patients based on their tumor localization. Colon cancer group involved patients with the tumor localized in the colon (n = 105, 52.24%) and rectal cancer group the patients with the tumor in the rectum (n = 96, 47.76%). Examining coagulation factors, univariate Cox analysis of colon cancer patients showed that activated partial thromboplastin time (p = 0.020) was significantly associated with overall survival, but we could not prove it in multivariate analysis. In colon cancer patients, neutrophil‐to‐lymphocyte ratio (NLR, p 
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.24128